Unintentional Weight Loss: Key Labs and Diagnostic Strategies

Initial Laboratory Investigations

• 💡 Hypothyroidism should be considered and tested for, as it's a common and treatable cause of weight loss.
• 📌 Checking B12 levels is recommended, especially in older patients who may have decreased intake or are on medications that affect absorption.
• ⚠️ Infectious causes like HIV or hepatitis C should not be overlooked, particularly in older patients where ageism might lead to under-testing.

Recommended Basic Lab Panel

• 🔬 A reasonable starting panel includes tests for liver function, glucose levels, TSH, B12, and screening for HIV and hepatitis C.
• 🎯 These basic tests cover common and treatable conditions contributing to weight loss.

Imaging Considerations

• 📊 The importance of reviewing all imaging, even if previous scans exist, is emphasized to ensure a thorough diagnostic approach.
• 🔍 This comprehensive review helps in identifying potential causes of weight loss that might have been missed or are not apparent from prior assessments.