Bladder Cancer: Over a Decade Cancer-Free with Anktiva, T-Cells & Immune Memory
[HPP] Patrick Soon-ShiongFebruary 2, 20263 min
6 connectionsΒ·9 entities in this videoβAddressing Immune System Collapse
- π‘ The core principle behind this treatment is that immune system collapse is the root cause of early mortality from both cancer and infection.
- π― The initial focus of this innovative approach was specifically on non-muscle invasive bladder cancer (NMIBC).
The Anktiva (N-803) + BCG Clinical Trial
- π A clinical trial for the Anktiva (N-803) plus BCG combination therapy commenced in 2014, involving patients who were initially BCG naive.
- β The trial demonstrated no dose-limiting toxicity, indicating the treatment was well-tolerated by participants.
- π¬ Patient testimonials, including one from Alvera who had a history of multiple cancers, highlighted the positive experience and hope derived from participating.
Mechanism of Immune Enhancement
- π¬ The N-803 therapy significantly increases the proliferation of T-cells, NK cells, and memory T-cells within the body.
- π§ A key discovery was the importance of memory T-cells in achieving a long duration of complete remission.
Unprecedented Durability and Patient Outcomes
- β¨ The therapy has shown remarkable durability, with many participants remaining cancer-free for nearly a decade.
- π Patients reported feeling "not scared anymore" and enjoying life, signifying a profound improvement in their quality of life.
- π A urologist with over 20 years of practice attested to the unprecedented durability observed in this clinical trial's results, offering a
Knowledge graph9 entities Β· 6 connections
How they connect
An interactive map of every person, idea, and reference from this conversation. Hover to trace connections, click to explore.
Hover Β· drag to explore
9 entities
Chapters1 moments
Key Moments
Transcript13 segments
Full Transcript
Topics14 themes
Whatβs Discussed
Immune system collapseBladder cancerNon-muscle invasive bladder cancer (NMIBC)Anktiva (N-803)BCG therapyClinical trialsT-cellsNK cellsMemory T-cellsComplete remissionImmune memoryCancer BioshieldOrgan function preservationLong-term remission
Smart Objects9 Β· 6 links
ProductsΒ· 2
EventsΒ· 2
ConceptsΒ· 4
PersonΒ· 1