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Bladder Cancer: Over a Decade Cancer-Free with Anktiva, T-Cells & Immune Memory

[HPP] Patrick Soon-ShiongFebruary 2, 20263 min
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Addressing Immune System Collapse

  • 💡 The core principle behind this treatment is that immune system collapse is the root cause of early mortality from both cancer and infection.
  • 🎯 The initial focus of this innovative approach was specifically on non-muscle invasive bladder cancer (NMIBC).

The Anktiva (N-803) + BCG Clinical Trial

  • 🚀 A clinical trial for the Anktiva (N-803) plus BCG combination therapy commenced in 2014, involving patients who were initially BCG naive.
  • ✅ The trial demonstrated no dose-limiting toxicity, indicating the treatment was well-tolerated by participants.
  • 💬 Patient testimonials, including one from Alvera who had a history of multiple cancers, highlighted the positive experience and hope derived from participating.

Mechanism of Immune Enhancement

  • 🔬 The N-803 therapy significantly increases the proliferation of T-cells, NK cells, and memory T-cells within the body.
  • 🧠 A key discovery was the importance of memory T-cells in achieving a long duration of complete remission.

Unprecedented Durability and Patient Outcomes

  • ✨ The therapy has shown remarkable durability, with many participants remaining cancer-free for nearly a decade.
  • 👏 Patients reported feeling "not scared anymore" and enjoying life, signifying a profound improvement in their quality of life.
  • 📈 A urologist with over 20 years of practice attested to the unprecedented durability observed in this clinical trial's results, offering a
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What’s Discussed

Immune system collapseBladder cancerNon-muscle invasive bladder cancer (NMIBC)Anktiva (N-803)BCG therapyClinical trialsT-cellsNK cellsMemory T-cellsComplete remissionImmune memoryCancer BioshieldOrgan function preservationLong-term remission
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