Skip to main content

Bladder Cancer: Over a Decade Cancer-Free with Anktiva, T-Cells & Immune Memory

[HPP] Patrick Soon-ShiongFebruary 2, 20263 min
6 connections·9 entities in this video→

Addressing Immune System Collapse

  • πŸ’‘ The core principle behind this treatment is that immune system collapse is the root cause of early mortality from both cancer and infection.
  • 🎯 The initial focus of this innovative approach was specifically on non-muscle invasive bladder cancer (NMIBC).

The Anktiva (N-803) + BCG Clinical Trial

  • πŸš€ A clinical trial for the Anktiva (N-803) plus BCG combination therapy commenced in 2014, involving patients who were initially BCG naive.
  • βœ… The trial demonstrated no dose-limiting toxicity, indicating the treatment was well-tolerated by participants.
  • πŸ’¬ Patient testimonials, including one from Alvera who had a history of multiple cancers, highlighted the positive experience and hope derived from participating.

Mechanism of Immune Enhancement

  • πŸ”¬ The N-803 therapy significantly increases the proliferation of T-cells, NK cells, and memory T-cells within the body.
  • 🧠 A key discovery was the importance of memory T-cells in achieving a long duration of complete remission.

Unprecedented Durability and Patient Outcomes

  • ✨ The therapy has shown remarkable durability, with many participants remaining cancer-free for nearly a decade.
  • πŸ‘ Patients reported feeling "not scared anymore" and enjoying life, signifying a profound improvement in their quality of life.
  • πŸ“ˆ A urologist with over 20 years of practice attested to the unprecedented durability observed in this clinical trial's results, offering a
Knowledge graph9 entities Β· 6 connections

How they connect

An interactive map of every person, idea, and reference from this conversation. Hover to trace connections, click to explore.

Hover Β· drag to explore
9 entities
Chapters1 moments

Key Moments

Transcript13 segments

Full Transcript

Topics14 themes

What’s Discussed

Immune system collapseBladder cancerNon-muscle invasive bladder cancer (NMIBC)Anktiva (N-803)BCG therapyClinical trialsT-cellsNK cellsMemory T-cellsComplete remissionImmune memoryCancer BioshieldOrgan function preservationLong-term remission
Smart Objects9 Β· 6 links
ProductsΒ· 2
EventsΒ· 2
ConceptsΒ· 4
PersonΒ· 1